In outpatients dependent on benzodiazepines, what medications can increase discontinuation rates?

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Evidence-Based Answer

The addition of imipramine or melatonin to a gradual benzodiazepine taper results in higher discontinuation rates than use of a placebo. Carbamazepine also helps with a benzodiazepine taper, but any eventual discontinuation is not sustained (SOR: B, meta-analysis of RCTs with heterogeneity and an individual RCT).

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