How often should serum protein electrophoresis be done in someone with monoclonal gammopathy of undetermined significance (MGUS)?

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Evidence-Based Answer

Patients with an initial diagnosis of MGUS should have a serum protein electrophoresis (SPEP) rechecked in 6 months. Risk stratification by free-light chain (FLC) ratio, immunoglobulin (Ig) type, and serum monoclonal (M) protein level is warranted. Low-risk patients should have SPEP every 2 to 3 years, while patients with higher-risk MGUS should have SPEP every year (SOR: C, expert opinion).

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