What are the risks and benefits of treating subclinical hypothyroidism (SCH) in the geriatric population?

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Evidence-Based Answer

SCH is associated with higher rates of coronary heart disease (CHD) mortality in patients aged 65 to 79 years (SOR: B, systematic review of cohort trials). Thyroid replacement therapy for SCH does not appear to be associated with an increased risk of worsening angina or atrial fibrillation (SOR: B, extrapolated from studies of mixed-aged patients). Long-term thyroid replacement in older adults with SCH may improve longevity (SOR: C, extrapolated from a small cohort study of mixed-aged patients).

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