What interventions improve outcomes for patients with isolated low levels of high-density lipoprotein cholesterol (HDL-C)?

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Evidence-Based Answer

Niacin, fibrates, and cholesteryl ester transfer protein (CETP) inhibitors may raise HDL, but do not improve cardiovascular outcomes compared with an active comparator (such as a statin). However, niacin and fibrates decrease nonfatal myocardial infarctions (MIs) compared with placebo (SOR: A, meta-analysis). Exercise alone, diet alone, and a combination of exercise and diet do not increase HDL (SOR: C, metaanalysis with disease-oriented outcomes).

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