What are the best pharmacologic smoking cessation options for patients with mental health conditions?

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Abstract

EVIDENCE-BASED ANSWER

Bupropion, with or without nicotine replacement therapy (NRT), as well as fluoxetine and paroxetine have no long-term effect on smoking cessation in patients with depression. Similarly, bupropion, with or without transdermal nicotine patches, and varenicline have no long-term effect on smoking cessation in patients with schizophrenia, even though rates of cessation may be higher at the conclusion of active treatment (SOR: A, meta-analyses of RCTs).

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