Is naltrexone effective for smoking cessation?

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No. Naltrexone does not have a significant effect on long-term (6 month) smoking abstinence (SOR: A, systematic review of quality RCTs). Adding naltrexone to nicotine replacement therapy (NRT) results in better 12-week quit rates in heavy alcohol drinkers, but not moderate to light drinkers or nondrinkers (SOR: B, RCT). Naltrexone 25 mg along with NRT results in less weight gain during smoking cessation therapy compared with nicotine replacement alone, but higher doses do not (SOR: B, RCT).

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