In hospitalized patients undergoing alcohol withdrawal, does fixed-dosing or as-needed (PRN) dosing of benzodiazepines result in better patient outcomes?

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Abstract

EVIDENCE-BASED ANSWER

Based on symptoms, as-needed dosing of benzodiazepines results in lower total dose of medication and shorter duration of treatment without a significant difference in complications compared with fixed dosing (SOR: A, consistent RCTs).

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