How effective are immune modulator injections of the globe in patients with wet macular degeneration?

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For patients with wet macular degeneration, intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) immune modulators such as ranibizumab, bevacizumab, or pegaptanib can prevent loss of visual acuity and, in some cases, improve visual acuity (SOR: A, meta-analysis). A newer agent, aflibercept, is noninferior to ranibizumab with the advantage of bimonthly injections instead of monthly (SOR: B, lower quality meta-analysis).

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