In patients with stroke, is warfarin better than aspirin plus clopidogrel for secondary prevention of stroke?

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Abstract

Bottom line

When compared with aspirin plus clopidogrel in patients with aortic arch atheroma, warfarin does not reduce the risk of recurrent stroke (SOR: B, single small RCT) and appears to be associated with a higher risk of bleeding (SOR: B, meta-analysis of RCTs). Antiplatelet agents should be used to reduce the risk of recurrent stroke in patients with aortic arch atheroma (SOR: A, evidence-based guideline based on consistent RCTs).

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