Are there effective medical treatments to prevent recurrent episodes of acute diverticulitis?

    loading  Checking for direct PDF access through Ovid



Currently, evidence is insufficient to recommend an ideal therapy. In patients with 1 episode of diverticulitis, cyclic therapy with rifaximin and fiber results in an absolute 1.9% decrease in 1-year recurrence of diverticulitis compared with fiber alone (SOR: B, meta-analysis of RCTs). In patients with 2 episodes, cyclic therapy with mesalazine and rifaximin leads to an absolute 15.2% reduction in recurrence of diverticulitis over 1 year compared with rifaximin alone (SOR: B, single RCTs). Mesalazine plus probiotics combined are more effective than probiotics alone (SOR: C, unblinded RCT). Prophylactic therapy with mesalazine alone and antibiotic treatment of initial acute diverticulitis do not alter recurrence rates (SOR: B, single RCTs).

Related Topics

    loading  Loading Related Articles