Are plasma or CSF amyloid beta levels helpful in predicting which patients with mild cognitive impairment will progress to Alzheimer's disease (AD) or other forms of dementia?

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Abnormal cerebral spinal fluid (CSF) and plasma amyloid beta (Aβ) levels are associated with cases of mild cognitive impairment (MCI) that later progress to dementia (SOR: B, meta-analysis of cohort studies). This association does not yet have clinical utility, as likelihood ratios are close to unity, and biomarker threshold levels predicting dementia are highly variable (SOR: B, metaanalysis of cohort studies and consensus guideline).

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