What is the rate of venous thromboembolism (VTE) in women taking combined oral contraceptives (COCs)?

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Abstract

EVIDENCE-BASED ANSWER

The rate of VTE in women taking COCs is approximately 0.06% per year. Third-generation and newer progestins (norgestimate, desogestrel, gestodene, drospirenone, and cyproterone acetate) are associated with greater risk of VTE (about 0.1% per year) (SOR: B, consistent findings from cohort studies).

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