What dose of thiamine should be used for prevention of Wernicke's encephalopathy?

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Abstract

EVIDENCE-BASED ANSWER

No consensus exists regarding the specific dose of thiamine that should be given for prevention of Wernicke's encephalopathy. Surrogate outcome measures for prevention of Wernicke-Korsakoff syndrome suggest 200 mg intramuscularly (IM) daily for 2 days is better than 5 mg IM for 2 days (SOR: B, RCT). It is recommended that more than 25 mg/d should be given parentally for at least 5 days followed by oral therapy (SOR: C, consensus guideline).

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