In patients with type 2 diabetes who are maximized on metformin with HbA1C above 7%, are GLP-1 agonists more effective than sulfonylureas for lowering HbA1C?

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Abstract

Bottom line

There is no convincing evidence that glucagon-like peptide-1 (GLP-1) agonists are more effective than sulfonylureas for lowering hemoglobin A1C (HbA1C) when added to metformin therapy (SOR: B, based on 2 meta-analyses with conflicting results).

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