In adults using antibiotics, do high-dose probiotics result in greater reduction of gastrointestinal symptoms than low-dose probiotics?

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Abstract

EVIDENCE-BASED ANSWER

Compared with low-dose probiotics, high-dose probiotics reduce duration of antibiotic-associated diarrhea (AAD) and certain gastrointestinal (GI) side effects associated with antibiotic use, such as fever, abdominal pain, bloating, abdominal distension, loose stools, and constipation (SOR: B, RCTs). High-dose probiotics may also reduce incidence of AAD and Clostridium difficile-associated diarrhea (CDAD) (SOR: B, conflicting RCTs). Data may be biased due to industry sponsorship of trials.

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