Is capsaicin cream safe and effective at reducing knee osteoarthritis pain?

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Capsaicin cream and its cis-isomer, civamide, have small to moderate effects reducing osteoarthritis knee pain after at least four weeks of use. Capsaicin cream is safe, but commonly causes application-site burning that rarely leads to stopping treatment (SOR: A, systematic review of RCTs and one crossover study).

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