Are antihistamines an effective treatment for drug-induced bone pain?

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Loratadine, given concurrently with granulocyte-colony stimulating factor (G-CSF), does not prevent bone pain more than placebo (SOR: B, single RCT). Hydroxyzine or astemizole (no longer available) given before or concurrently with G-CSF, are associated with less growth factor-induced bone pain (SOR: C, prospective cohort study and case reports).

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