In adults with insomnia, are antidepressants with sedative effects (trazodone and doxepin) more effective than placebo in improving sleep?

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Abstract

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Yes. Sedative antidepressants are more effective than placebo for increasing total sleep time and decreasing sleep onset latency as measured by polysomnography (SOR: A, meta-analysis of RCTs and small subsequent RCT).

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