How long can terbinafine be safely used for onychomycosis treatment?

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Abstract

EVIDENCE-BASED ANSWER

Terbinafine appears safe when used for 12 weeks, with a low (0.04%) incidence of drug-induced liver injury or serious adverse events (SOR: B, postmarketing surveillance). Longer durations of therapy may be associated with increased risk of liver toxicity (SOR: C, modeling based on case-controlled study).

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