What are the best treatments for actinic keratosis?

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For complete clearance of lesions, 5-fluorouracil, diclofenac, imiquimod, and ingenol mebutate are more effective than placebo. Of these agents, 5-fluorouracil is the most effective. For individual lesions, photodynamic therapy is superior to cryotherapy (SOR: A, meta-analysis of RCTs, network analysis of RCTs).

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