In patients with fibromyalgia, is low-dose naltrexone effective in alleviating pain, and does it decrease use of oral opioids?

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Used alone, low-dose naltrexone modestly reduces pain compared with placebo. No studies have addressed the effect of low-dose naltrexone on oral opioid use in patients with fibromyalgia (SOR: B, single small RCT and single nonrandomized pilot study).

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