What percentage of advanced colonic neoplasms can be found by colonoscopy, flexible sigmoidoscopy, and stool guaiac?

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Colonoscopy detects about 98% of large (≥10 mm) adenomas (SOR: A, meta-analysis of cohort studies). When colonoscopy is used as the reference standard, simulated flexible sigmoidoscopy has a sensitivity for detecting any advanced colonic neoplasm throughout the colon of 70% to 86% (SOR: A, systematic review of cohort studies) and a single stool guaiac test is 50% to 65% sensitive for detecting colorectal cancer (SOR: B, small prospective cohort study with a case-control arm).

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