What are the benefits and risks of using atypical antipsychotic agents in children with disruptive behaviors?

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Risperidone is moderately effective in decreasing aggression and conduct problems in children with disruptive behaviors, but may be associated with increased appetite, weight gain, hyperprolactinemia, and gastrointestinal symptoms (SOR: A, a meta-analysis of effects and systematic review of harms). Quetiapine, aripiprazole, and ziprasidone may also be effective, but quetiapine can cause weight gain (SOR: C, low-quality RCT and cohort study).

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