What is the most appropriate treatment for asymptomatic bacteriuria in pregnancy?

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The answer is unclear. Seven days of nitrofurantoin was better than a single day of nitrofurantoin, but no difference was found between fosfomycin and cefuroxime and no difference between 1 day and 4 to 7 days of co-trimoxazole, trimethoprim, amoxicillin, ampicillin, sulfamethoxazole, or cephalexin (SOR: B, meta-analyses of heterogeneous RCTs). The Infectious Diseases Society of America recommends treatment for 3 to 7 days but does not favor a specific antibiotic (SOR: B, evidence-based guideline).

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