What is the risk of esophageal adenocarcinoma in patients with Barrett's esophagus?

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Abstract

EVIDENCE-BASED ANSWER

The risk of esophageal adenocarcinoma (EAC) in patients with Barrett's esophagus (BE) is estimated to be 0.12% to 0.63% annually (SOR: A, meta-analysis of longitudinal studies and 2 population-based studies). Risk factors for progression to EAC include male sex, more than 3 cm of Barrett's mucosa, and dysplasia or metaplasia on index biopsy (SOR: B, 1 population-based study).

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