In pediatric patients on antibiotic therapy, do probiotics prevent antibiotic-associated diarrhea?

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Yes, co-administering probiotics at high doses with antibiotics in children younger than 18 years old is associated with a 48% reduction in the incidence of antibiotic-associated diarrhea (SOR: B, meta-analysis of RCTs at risk of bias). Probiotic administration with antibiotic therapy also results in a 60% reduction in the incidence of Clostridium difficile-associated diarrhea (CDAD) (SOR: B, extrapolated from a meta-analysis including adults and children).

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