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Maybe. Pooled evidence from RCTs reveals no reduction in productive cough with use of beta-2-agonists (SOR: B, meta-analysis of 2 small RCTs). When the RCTs were evaluated separately, albuterol led to a 30% absolute decrease in cough at 7 days but had no effect on nighttime cough or productive cough. Fenoterol reduced productive cough but not total daytime or nighttime cough (SOR: C, small RCTs).