What is the best clinical scale to diagnose major depressive disorder in patients with dementia?

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EVIDENCE-BASED ANSWERThe available options are only somewhat useful. The Cornell Scale for Depression in Dementia (CSDD) is only marginally sensitive for diagnosing depression in patients with dementia, with a positive likelihood ratio (LR+) of 1.6. The Geriatric Depression Scale (GDS-30) correlates moderately with the CSDD in patients with mild cognitive impairment but only weakly in patients with Alzheimer's dementia (SOR: B, prospective cohort studies).

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