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The Step-by-Step approach is the most sensitive algorithm for the management of infants with fevers without a source in the emergency department (ED), allowing providers to decrease invasive testing and antibiotic treatment of low-risk infants.Strength of recommendation: B, based on a multicenter prospective studyGomez B, Mintegi S, Bressan S, Da Dalt L, Gervaix A, Lacroix L; European Group for Validation of the Step-by-Step Approach. Validation of the “Step-by-Step” approach in the management of young febrile infants. Pediatrics. 2016; 138(2). doi: 10.1542/peds.2015–4381.