How effective is caffeine plus an analgesic for treating acute postoperative or postpartum pain in adults?

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Abstract

EVIDENCE-BASED ANSWER

Caffeine at doses of 100 mg or more as an adjunct to analgesics may be slightly more effective than analgesics alone for acute postoperative or postpartum pain in adults and is significantly better than placebo alone (SOR: A, based on systematic reviews RCTs and a subsequent RCT).

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