Is the addition of fish oil to statin therapy in patients with persistent hypertriglyceridemia more effective than statins alone?


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Abstract

EVIDENCE-BASED ANSWERYes. Adding prescription-strength fish oil, or omega-3 fatty acids (OM3FA), to statin therapy is associated with an additional 20% to 30% reduction in triglyceride (TG) concentrations, but the effect on cardiovascular disease outcomes is not known (SOR: C, RCTs with diseaseoriented evidence). Addition of OM3FA is recommended if TG concentrations remain significantly elevated despite statin therapy (SOR: C, expert opinion).

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