Does morning or evening administration of long-acting insulin affect glycemic control in patients with type 2 diabetes?

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Abstract

EVIDENCE-BASED ANSWER

The timing of long-acting insulin injection has no difference on fasting blood glucose reductions or pharmacokinetics (SOR: C, RCTs with disease-orientated outcomes). However, evening administration leads to fewer patients experiencing symptomatic hypoglycemia than morning administration, with no difference in total hypoglycemic or nocturnal hypoglycemic events (SOR: B, single RCT).

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