Do SGLT-2 inhibitors improve cardiovascular outcomes in patients with type 2 diabetes?

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Yes. In patients with type 2 diabetes, treatment with sodium glucose cotransporter 2 (SGLT2) inhibitors lead to a 30% to 40% decreased risk of cardiovascular death and a 30% decreased risk death from any cause. They also lead to reductions in other major adverse cardiovascular outcomes including new-onset heart failure and hospitalization due to heart failure (SOR: A, meta-analyses of RCTs, heavily influenced by 1 RCT).

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