Is an isolated elevation of maternal human chorionic gonadotropin (hCG) associated with adverse fetal outcomes?

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EVIDENCE-BASED ANSWERAn isolated elevation in hCG is associated with an increased risk of preterm birth and fetal death (SOR: C, inconsistent case-control studies). Elevated hCG is not associated with increased risk of intrauterine growth restriction (IUGR), small-for-gestational-age (SGA) infants, low Apgar scores, or early preterm birth (SOR: C, consistent case-control studies). Among women with preeclampsia and elevated hCG, there is an increased risk of preterm birth, low birth weight, and newborn intensive care unit (NICU) admission (SOR: C, casecontrol study).

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