What is the best treatment for erectile dysfunction in men with diabetes mellitus?

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Phosphodiesterase type 5 (PDE-5) inhibitor therapy is superior to placebo for erectile dysfunction (ED) in patients with and without diabetes. No studies directly compare PDE-5 inhibitors (SOR: A, systematic review and RCT). Testosterone treatment may improve sexual function in patients with diabetes and severe hypogonadism (SOR: C, single RCT).

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