Do antibiotics improve outcomes in the management of acute uncomplicated diverticulitis?

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No, antibiotics do not appear to reduce the complication rate, length of hospital stay, or recurrences in the treatment of acute uncomplicated diverticulitis (without abscess, fistula, free air, peritonitis, sepsis, or immune suppression). Complication rates in uncomplicated diverticulitis are 1% to 3% with or without antibiotics (SOR: B, single highquality RCT and 2 observational studies conducted by 1 research group).

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