What nonnarcotic oral analgesics are the safe for patients taking warfarin?

    loading  Checking for direct PDF access through Ovid

Abstract

EVIDENCE-BASED ANSWER

The answer is not entirely clear. COX-2 inhibitors appear safer than nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) for patients taking warfarin (SOR: B, cohort and case-control studies). Acetaminophen increases the international normalized ratio (INR) in patients taking warfarin by 0.67 to 0.83 over placebo, but with unclear clinical effect (SOR: C, small RCTs with disease-oriented outcomes).

Related Topics

    loading  Loading Related Articles