What is the efficacy of medication versus CBT or both for the treatment of depression in adolescents?

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EVIDENCE-BASED ANSWERAt 3 months, fluoxetine alone is about as effective as the combination of fluoxetine and cognitive behavioral therapy (CBT) and either is more efficacious than CBT alone. However, by 9 months, these differences disappear and all 3 treatments appear equivalent (SOR: B, RCT with follow-up study).

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