Are phosphodiesterase inhibitors effective and safe for men with diabetes and erectile dysfunction?

    loading  Checking for direct PDF access through Ovid

Abstract

EVIDENCE-BASED ANSWER

Yes. As-needed use of sildenafil, tadalafil, and vardenafil lead to large improvements in erectile function in men with diabetes. Tadalafil taken daily results in nearly 20% more men able to complete intercourse, but only marginal clinical benefit in overall erectile function compared with placebo. Adverse events occur up to twice as often with phosphodiesterase type 5 (PDE-5) inhibitors than placebo, but are minor such as headache and dyspepsia (SOR: A, meta-analyses of RCTs). Vardenafil taken daily improves global erectile function scores, with mean scores at the level considered to be normal erectile function (SOR: B, single RCT).

Related Topics

    loading  Loading Related Articles