Does hypertonic saline infusion with furosemide improve outcomes for patients with acute CHF exacerbation?

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Perhaps. In patients treated for acute congestive heart failure (CHF), hypertonic saline infusion with furosemide decreases all-cause mortality by 44%, hospital readmission rates by 50%, and length of stay by about 3 days compared with furosemide alone (SOR: B, meta-analysis of lower quality RCTs and small RCT). However, patients in these studies were not consistently on current guideline-directed medical therapy.

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