Can procalcitonin testing guide antibiotic therapy in children with communityacquired pneumonia?

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EVIDENCE-BASED ANSWERMeasuring procalcitonin levels in children with pneumonia can decrease antibiotic use, shorten antibiotic duration by 3 to 5 days, and decrease antibiotic-related adverse effects. A procalcitonin level of more than 3 ng/mL is a better predictor of clinical response to antibiotics than C-reactive protein (CRP) or white blood cell count (WBC) (SOR: B, 2 RCTs and a cohort study).

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