Is quetiapine effective for the treatment of insomnia and how does it compare with other medications?

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Quetiapine does not seem to be any better than placebo for treatment of primary insomnia (SOR: C, small, underpowered RCT). In populations with induced insomnia and mixed insomnia, quetiapine appears about equal to mirtazapine (SOR: C, small RCT) and trazodone (SOR: C, small prospective cohort study).

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