Does a family history of adenomatous colon polyp(s) in a first-degree relative pose an increased risk of developing colon cancer?

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Abstract

EVIDENCE-BASED ANSWER

Yes. A positive family history of adenomatous polyps doubles a person's risk for developing colorectal cancer (SOR: B, meta-analysis of case-control trials and a casecontrol study). Similarly, patients with adenomas are 40% more likely to have a family history of colon cancer than patients without polyps (SOR: B, cohort trial).

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