In premenopausal women with low sexual desire, is flibanserin (Addyi®) an effective and safe treatment?

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EVIDENCE-BASED ANSWERIn premenopausal women with female sexual interest/arousal disorder (FSIAD), flibanserin marginally increases the number of satisfying sexual events per month and minimally improves desire, while significantly increasing dizziness, somnolence, nausea, and fatigue (SOR: B, meta-analysis of low-quality RCTs). Adverse events of flibanserin increase when combined with alcohol (SOR: C, small RCT).

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