For an ulcerative colitis flare up, what is first-line outpatient therapy?

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In mild to moderate ulcerative colitis flares, oral 5-aminosalycilates (5-ASA) is equivalent to sulfasalazine with fewer adverse effects (SOR: A, meta-analysis of RCTs). Rectal 5-ASA is equivalent to oral 5-ASA and superior to rectal steroids (SOR: A, meta-analysis of RCTs). For moderate to severe flares, oral corticosteroids are recommended (SOR: C, expert opinion).

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