Are second-generation antipsychotics as effective as mood stabilizers for maintenance treatment of bipolar affective disorder?

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Second-generation antipsychotics have similar efficacy in preventing recurrence of extreme mood events as mood stabilizers when used as chronic therapy for patients with bipolar affective disorder (SOR: B, meta-analysis of RCTs without direct comparison). Quetiapine is more effective than placebo and of similar efficacy to lithium for preventing recurrence of any mood event (SOR: B, single RCT).

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