How well do commercially available point-of-care tests diagnose rupture of membranes?

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Abstract

EVIDENCE-BASED ANSWER

For women with clinically suspected rupture of membranes (ROM), commercially available placental alpha microglobulin-1 (PAMG-1) may be superior to insulin-like growth factor binding protein-1 (IGFBP-1) for determining membrane status (SOR: A, meta-analyses of diagnostic cohort studies). A commercially available combination monoclonal and polyclonal immunoassay may be better than conventional methods (pooling, ferning, or positive Nitrazine paper) at ruling out ROM but not at ruling in ROM (SOR: B, prospective diagnostic cohort study).

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