Does vitamin C, as an adjunct to betablocker therapy, decrease the incidence of post-CABG atrial fibrillation?

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The answer is unclear. Smaller, unblinded trials indicate vitamin C given orally pre- and postoperatively as an adjunct to beta-blockers decreases the incidence of post-coronary artery bypass grafting (CABG) atrial fibrillation as did a larger, blinded trial using intravenous (IV) ascorbic acid. However, the largest blinded trial failed to find a difference with oral ascorbic acid (No SOR given).

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