Does testing C-reactive protein add important information to standard coronary artery disease risk assessment?

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Abstract

EVIDENCE-BASED ANSWER

High-sensitivity C-reactive protein (hsCRP) may help stratify patients at intermediate risk of coronary artery disease based on standard risk profiling. When hsCRP is added to algorithms using standard risk factors, 5.2% of patients at intermediate risk of cardiovascular disease would be reclassified into a higher-risk group in which statins are recommended (SOR: B, predictive modeling of data from a meta-analysis of prospective cohort studies). Checking hsCRP levels may be considered for intermediate-risk and low-risk patients in whom the decision to start a statin is unclear (SOR: C, consensus guidelines).

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