Does the use of N-acetylcysteine decrease the risk of contrast-induced nephropathy?

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EVIDENCE-BASED ANSWERProbably. Although pooled data including low- and highdose regimens of N-acetylcysteine (NAC) in combination with a hydration protocol did not decrease risk of contrast-induced nephropathy (SOR: B, meta-analysis of heterogenous RCTs), doses of NAC of more than 600 mg every 12 hours decrease the risk of contrastinduced nephropathy in patients with baseline renal insufficiency (SOR: A, meta-analysis of RCTs).

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